Oligonucleotide therapies for disorders of the nervous system

Cell replacement therapies for nervous system regeneration.

The adult brain was thought to be a slowly decaying organ, a sophisticated but flawed machine condemned to inevitable decline. Today we know that the brain is more plastic than previously assumed, as most prominently demonstrated by the constitutive birth of new neurons that occurs in selected regions of the adult brain, even in humans. However, the overall modest capacity for endogenous repair...

O 14: Differentiating Demyelinating Disorders of the Central Nervous System – a Focus on Multiple Sclerosis and Neuromyelitis-Optica Spectrum Disorders

Significant advances have been made in diagnosis and therapy of demyelinating disorders of the central nervous system. The most common entities of this disorders in adults – multiple sclerosis and neuromyelitis optica were initially thought to be different phenotypes of more or less the same disease. During the last ten years, this view was subsequently changed and the term neuromyelitis ...

Therapies Targeting the Nervous System for Chronic Pelvic Pain Relief

Gene-targeted therapies for the central nervous system.

T he identification of the genes and proteins involved in many neurodegenerative diseases offers the exciting possibility of modifying those disease-linked proteins to develop novel, targeted therapies for diseases such as amyotrophic lateral sclerosis (ALS) or Huntington disease. In many of these diseases, the simplest modification— decreasing the amount of the offending protein—may represent ...

Therapies Targeting the Nervous System for Chronic Pelvic Pain Relief